Synjardy, A medicine to live a better life with Diabetes. A two-in-one combination to control sugar levels in Type-2 Diabetes and giving a positive attitude of living. Before diving in deep, let’s start by knowing about the medication and moreover, What is Synjardy used for?
What is Synjardy?
Synjardy (Composition of Empagliflozin and Metformin). Empagliflozin and Metformin are the two medications included in this medicine. An FDA-approved brand-name prescription medication for individuals with type 2 diabetes is called Synjardy.
Combining a nutritious diet and regular exercise with the drug Synjardy can help lower blood sugar levels. This was the introduction of the medication: Synjardy. Now let you move forward to understand and relate, what is Synjardy used for?
It is used to manage high blood sugar levels in persons with Type 2 diabetes together. But medication only is never the solution. The solution comes with a healthy diet and exercise regimen together with the right doses of the medicine. No doctor or physician will suggest a medication for diabetes without moving a muscle or motivating yourself for some exercise.
Keeping blood sugar levels under control helps avoid problems with sexual function, renal damage, blindness, and other health difficulties. If your diabetes is under control, your risk of having a heart attack or stroke may be decreased.
The way that this drug works is by assisting in restoring your body’s appropriate reaction to the insulin that you naturally make. Also, it lessens the amount of sugar your liver produces, your kidneys remove more of it, and your body absorbs less of it through your stomach and intestines.
How to use Synjardy?
- It is recommended to take Synjardy twice daily, with breakfast and dinner.
- These tablets cannot be chewed, split, crushed, or dissolved, according to the manufacturer.
- Speak to your doctor or pharmacist if you are having problems swallowing Synjardy tablets as a whole.
- Take one dose of Synjardy with breakfast each day and make sure to finish the entire tablet.
- They must not be broken, divided, dissolved, or chewed.
- It will harm their extended-release action if you do that, this is not what is Synjardy used for.
- See your physician or pharmacist if you are having problems swallowing the complete tablets.
Synjardy Side Effects:
The more frequent side effects of Synjardy can include:
- Bloating, gas, or diarrhea
- Headache with indigestion
- Low vitamin B12 level gastrointestinal illness
- Urinary tract infection and an uneasy stomach
- Weakness
- Diseases of the upper respiratory tract, like the common cold
- Joint discomfort
- Increased urination
- Fungal genital infections in men
Severe adverse reactions and accompanying signs may include
- Hypoglycaemia or commonly said to be low blood sugar level. Other signs include perplexed behavior.
- Dizziness with mood swings or anxiety consciousness loss
- Shakiness with sweating
- Hypotension (low blood pressure)
- Variations in blood levels of the protein creatinine, which can indicate renal impairment
- A rise in LDL cholesterol, or low-density lipoprotein cholesterol.
- Allergic response
- The gangrene of Fournier (severe infection near your genitals)
- Ketoacidosis (accumulation of ketones in your body, which causes your blood to become overly acidic).
- Laxative acidosis (increased acid level in your blood)
There are many uses of Synjardy but there can be associated negative effects too, one being weight loss. So does Synjardy cause weight loss?
Throughout 24 weeks of treatment, persons taking Synjardy lost 2.5% to 2.9% of their body weight, according to clinical trials. Participants in the research began at an average weight of roughly 180 pounds (around 82 kilograms). Thus this suggests that on average, people shed around 5.5 pounds (2.5 kilograms) of body weight over the trial.
It is also seen that the medication causes appetite loss which in turn causes weight loss.
Synjardy Dosage:
Synjardy Tablet Dosage Forms:
- 5mg/500mg
- 12.5mg/500mg, 5mg/1000mg, 12.5mg/1000mg
Synjardy Customary Dosage:
- Synjardy (For immediate release). The starting dose of your diabetes drugs will depend on the previous dose. Two oral doses of Synjardy should be taken with meals each day. Depending on how you respond to the drug, your doctor may change the dose you are given. Limit your daily dosage of empagliflozin and metformin to 25 mg/2,000 mg.
- The starting dose of Synjardy XR (extended-release) will depend on the dosage of your previous diabetes treatments. When taken orally once daily in the morning with food, Synjardy XR is recommended. Depending on how you respond to the drug, your doctor may change the dose you are given.
Overdose:
If you suspect that you have taken too much Synjardy, the intended measure and this is not advised, what is Synjardy used for. Call your doctor right away. To help the medicine leave your body, a medical procedure might be necessary. You can also phone 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource. Call 911 (or your local emergency number) right away if you are experiencing severe symptoms, or get to the closest medical room.
Drug Interactions:
Metoprolol, propranolol, and glaucoma eye drops like timolol are examples of beta-blocker drugs that may lessen the fast, pounding heartbeat you often experience when your blood sugar levels drop too low (hypoglycemia). These medications have little effect on other low blood sugar symptoms like weakness, hunger, or sweating.
Many medications might alter your blood sugar, making it more difficult to manage. Before starting, stopping, or altering any medicine, talk to your doctor or pharmacist about any potential effects on your blood sugar. As directed, monitor your blood sugar levels periodically, and report the results to your doctor. If you experience high or low blood sugar symptoms, contact your doctor right away.
Storage:
- Tablets of Synjardy should be kept away from light in a firmly sealed container at room temperature (77°F or 25°C).
- Avoid keeping this medication in restrooms or other locations where it might get wet. Ensure that Synjardy is kept out of children’s reach.
How does Synjardy work?
The mechanism of action of Synjardy is as follows:
The medicine Synjardy combines metformin, a member of the Biguanides class, and empagliflozin, an inhibitor of the sodium-glucose co-transporter 2 (SGLT2) enzyme, to enhance glycemic control in persons with type 2 diabetes..
Empagliflozin:
The primary transporter responsible for the reabsorption of glucose from the glomerular filtrate back into circulation is Empagliflozin. Sodium-Glucose Co-Transporter 2 (SGLT2). SGLT2 is inhibited by Empagliflozin. Empagliflozin increases urine glucose excretion by decreasing renal reabsorption of filtered glucose and lowering the renal glucose threshold. This is accomplished by inhibiting SGLT2.
Metformin:
By reducing both baseline and postprandial plasma glucose, the anti-hyperglycemic drug metformin improves glucose tolerance in people with Type 2 diabetes mellitus. It is not chemically or pharmacologically related to any other classes of oral antihyperglycemic medications.
Metformin enhances insulin sensitivity by boosting peripheral glucose uptake and utilization, decreasing hepatic glucose synthesis, and decreasing intestinal glucose absorption. This illustrates what is Synjardy used for.
Being so vast in its usage. Synjardy also raises some questions. For instance, Does Synjardy cause Diarrhea? Another question is Does Synjardy cause hair loss?
Let’s dive into the first query. One of the drugs used to make Synjardy work is metformin, which frequently causes diarrhea as a side effect. Diarrhea is thought to be the reason why 5% of metformin users cease using the medication.
Diarrhea is a possibility while taking Synjardy because it contains metformin. Remember that the majority of patients who experience diarrhea as a side effect do so only in the first few weeks of therapy. But, even if you’ve been taking Synjardy for a long period, the adverse effect could still happen at any time.
This medication is not recommended to take on an empty stomach. It requires to be taken with meals or after meals. Doing so might even assist in reducing your chance of experiencing drug-related diarrhea.
If you get diarrhea while using Synjardy, consult your physician. They might change your medication to an extended-release version (called Synjardy XR). You may be able to lower your risk of diarrhea by doing this.
Furthermore, rarely, there can be a connection between taking medicines having metformin and hair loss. Metformin may indirectly contribute to hair loss. Throughout Synjardy’s clinical studies, no cases of hair loss were reported. Discuss potential reasons and treatments for hair loss with your doctor if you are worried about the medicine and its effect and what is synjardy used for.
When Should I take Synjardy?
It is recommended to take Synjardy twice daily, with breakfast and dinner. There are two different types of Synjardy, and each one needs to be ingested together with food. Depending on which of the following formats you’re taking the drug in, you’ll need to take it at certain times:
- Synjardy: Take Synjardy in this immediate-release version twice daily with meals.
- Synjardy XR: Take this extended-release version of Synjardy once daily with breakfast.
An easier way is setting a reminder on your smart-phone to make sure you don’t forget to take a dose. This scheduling can be very helpful to avoid skipping dosage. Moreover, a medication timer could be helpful as well.It is not advisable to crush, chew or split up the medicine.
How much does Synjardy cost?
Depending on the pharmacy you go to, the cost of a Synjardy oral tablet (12.5 mg-500 mg) for a supply of 60 pills roughly ranges from $650-$740. The listed costs are for cash-paying consumers and are not valid with insurance policies.
In addition to diet and exercise, people with Type 2 diabetes who take Synjardy can control their blood sugar levels. Those who have both Type 2 diabetes and heart disease can take it to reduce their chance of dying from cardiovascular causes. With LifeRx Pharmacy, one can avail good discounts on Synjardy. It can help you save upto 80% on the cost of prescription drugs.
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FAQs:
How long does it take for Synjardy to work?
Within the first 1 to 2 weeks, Jardiance may start to lower your blood sugar levels positively. Yet, Synjardy is an oral medication that is frequently taken for the long term by people with type 2 diabetes and has advantages for heart health and weight loss.
How long does Synjardy stay in your system?
It stays in the system for a few days to a couple of weeks.
Does Synjardy cause yeast infections?
Yes, Females may occasionally get vaginal yeast infections as a result of Synjardy. The vaginal area may experience soreness and itching as symptoms, which could make having intercourse difficult or uncomfortable. It also develops a vaginal odor, white or yellowish discharge (which may be lumpy or resemble cottage cheese), and/or vaginal itching.
Does Synjardy make you pee a lot?
The possibility exists that Synjardy will cause you to urinate more frequently than usual. The medication increases the amount of sugar your kidneys excrete in your urine. When your pee contains a lot of sugar, it draws water from your body and into your urine. You may urinate more frequently than normal as a result of this.
Is Synjardy safe?
Yes, Synjardy is safe.
Is there a generic for Synjardy?
No, the sole form of Synjardy on the market is a brand-name drug. There isn’t a generic version available right now.
Can you take Synjardy and Metformin together?
No, it is not suggested to take Synjardy and Metformin together as Synjardy’s active ingredient also contains Metformin. Combining can lead to overdose.
Is Synjardy Insulin?
No. Remember that Synjardy is not intended to treat type 1 diabetes which is insulin-dependent. Combining a nutritious diet and regular exercise with the drug Synjardy can help lower blood sugar levels. The two active medications in Synjardy are Metformin (Glucophage) and Empagliflozin (Jardiance). This sums up the question on the medicine and now it is comprehensive, what is Synjardy used for.
