What is Xadago?
Xadago (safinamide) is a prescription medication used in the treatment of Parkinson’s disease, specifically in patients experiencing “off” episodes—times when other medications aren’t working well. What is Xadago for Parkinson’s is typically prescribed as an add-on therapy to a combination of levodopa/carbidopa.
Xadago is taken once daily and is not usually used as a standalone treatment. It helps smooth out fluctuations in symptoms, allowing patients with Parkinson’s disease to enjoy more “on” time throughout the day. Always consult a neurologist to understand if Xadago is the right option for you.
How does Xadago work in the brain?
Xadago works by inhibiting monoamine oxidase-B (MAO-B), an enzyme that breaks down dopamine in the brain. How does Xadago work? By blocking this enzyme, Xadago helps increase and prolong dopamine levels, improve motor function, and reduce symptoms like tremors, stiffness, and slowness of movement.
It may also affect glutamate release, offering additional symptom control beyond traditional dopaminergic therapy.
The Role of Xadago in Parkinson’s Disease
What is Xadago for Parkinson’s
Xadago (safinamide) plays an important role in managing motor fluctuations in patients with Parkinson’s disease. It is specifically used as an add-on treatment for individuals who are already taking levodopa but continue to experience “off” episodes—periods when the medication’s effects wear off and symptoms return. What is Xadago?
It’s a medication that works by inhibiting the MAO-B enzyme, which helps increase the levels and duration of dopamine activity in the brain, a key chemical involved in movement control. Additionally, it modulates glutamate release, which may offer further Xadago for mobility improvement in motor symptoms and reduce involuntary movements (dyskinesia) in some cases.
By prolonging the effects of existing dopaminergic therapy, Xadago for mobility improvement aids in better motor control, increases “on” time, and enhances overall quality of life in people living with Parkinson’s disease.
Why Mobility Declines in Parkinson’s Patients?
Mobility declines in Parkinson’s disease due to the progressive loss of dopamine-producing neurons in the brain. Dopamine is essential for smooth and coordinated muscle movements. As its levels decrease, patients begin to experience stiffness, slowness (bradykinesia), tremors, and postural instability. Over time, these symptoms affect balance, walking speed, and coordination, making daily tasks more difficult.
Parkinson’s can also cause muscle rigidity and reduced arm swing, leading to a shuffling gait or freezing episodes, where a person temporarily feels stuck and unable to move. This decline isn’t just physical; fatigue, depression, and cognitive changes can also reduce activity levels, further impacting mobility. Early intervention with medication, physical therapy, and movement strategies can help preserve mobility for longer.
What is Xadago, and how does Xadago support motor function?
Xadago (safinamide) supports motor function in Parkinson’s patients by enhancing and extending the effect of dopamine in the brain. It works primarily as a selective MAO-B inhibitor, which means it blocks the enzyme that breaks down dopamine. This leads to higher and more sustained dopamine levels, helping improve control over movement.
In addition, Xadago has glutamate-modulating properties, which may reduce excessive neuronal activity that contributes to motor complications like dyskinesia. Together, these actions help reduce stiffness, slowness, and tremors while increasing “on” time—periods when Parkinson’s symptoms are better managed and mobility is improved.
Recommended Xadago Dosage
Xadago dosage for Parkinson’s is 50 mg once daily via the oral route. Depending on the patient’s response and tolerance, the dose may be increased to 100 mg once daily after two weeks. Xadago is usually prescribed as an add-on therapy to levodopa/carbidopa and is taken at the same time each day, with or without food.
It’s important not to exceed the recommended dose and to follow your neurologist’s guidance, as dosage adjustments depend on individual health factors and response to treatment.
What are the side effects of Xadago?
Xadago (safinamide) is generally well tolerated, but like all medications, it may cause side effects in some individuals. Common side effects of Xadago include nausea, insomnia, headache, and dizziness. Some patients may experience increased blood pressure or falls, especially the elderly.
In rare cases, Xadago may lead to hallucinations, confusion, or impulse control issues, particularly when used with other dopaminergic drugs. It’s important to monitor for any new or worsening symptoms and consult your doctor if they occur. Regular follow-up helps ensure the medication remains both safe and effective.
Who should avoid taking Xadago?
Xadago (safinamide) should be avoided by individuals with severe liver impairment, as the drug is metabolized in the liver and could accumulate to harmful levels. It is also not recommended for patients taking other monoamine oxidase (MAO) inhibitors, opioids, or certain antidepressants (like SSRIs or SNRIs), due to the risk of serotonin syndrome or hypertensive crisis.
People with a history of psychosis or impulse control disorders should use Xadago with caution, as it may worsen these conditions. Always consult your doctor to ensure Xadago is safe based on your medical history and current medications.
Cost of Xadago
The cost of Xadago can vary based on factors like dosage, pharmacy, and insurance coverage. It’s advisable to consult with your healthcare provider or pharmacist to explore these options and determine the most cost-effective solution for your treatment.
FAQs
How long does it take for Xadago to improve mobility?
Xadago may begin to improve mobility within 1 to 2 weeks of starting treatment, though noticeable benefits are often seen after a few weeks of consistent use. Its effect is most evident when used as an add-on to levodopa therapy, helping extend “on” time and reduce motor fluctuations. Individual responses may vary, so regular follow-ups with your doctor are important to assess progress.
What are the best exercises for Parkinson’s?
The best exercises for Parkinson’s include walking, cycling, tai chi, and stretching, as they help improve balance, flexibility, and coordination. Strength training supports posture and muscle tone, while dance or rhythmic movements can aid in gait and mobility. Regular physical activity can slow symptom progression and enhance quality of life. Always consult a physiotherapist for a tailored routine.
How can I improve Parkinson’s mobility?
To improve mobility in Parkinson’s, focus on regular exercise, including balance, strength, and flexibility training. Medications like levodopa or Xadago can help reduce stiffness and improve movement. Physical and occupational therapy offer personalized strategies to stay active. Maintaining a routine and staying mentally engaged also play a key role in supporting mobility.
What helps Parkinson’s patients walk?
Parkinson’s patients can improve walking with the help of medications like levodopa or Xadago, which reduce stiffness and improve motor control. Physical therapy and gait training exercises enhance balance and coordination. Techniques such as cueing (like stepping to a beat) and using walking aids can also make walking easier and safer. Regular movement and routine practice are key.
How to strengthen legs with Parkinson’s?
To strengthen legs with Parkinson’s, focus on leg-specific exercises like seated leg raises, squats using a chair, and step-ups with support. These build muscle strength and improve stability. Resistance bands can be helpful for gentle strength training. Working with a physiotherapist ensures safety and proper form while maximizing results.
What are the benefits of Xadago?
Xadago offers several benefits for people with Parkinson’s disease. It helps prolong “on” time when motor symptoms are better controlled and reduces “off” time when symptoms return. Xadago also enhances the effects of levodopa, improving mobility and motor control. Additionally, it may help lessen involuntary movements (dyskinesia) and support overall quality of life.
When to take Xadago?
Xadago is typically taken once daily, with or without food, as prescribed by your doctor. It’s often added to an existing levodopa-based treatment in mid-to-late stages of Parkinson’s disease to help manage motor fluctuations. For best results, take it at the same time each day. Always follow your neurologist’s guidance for timing and dosage.
What if I miss a dose of Xadago?
If you miss a dose of Xadago, take it as soon as you remember on the same day. However, if it’s almost time for your next dose, skip the missed one—do not double up to make up for it. Taking extra doses can increase the risk of side effects. Always try to take your medication at the same time daily for consistent benefits.
What to avoid while taking Xadago?
While taking Xadago, avoid using other MAO inhibitors or certain antidepressants, as they can cause serious interactions. Steer clear of high-tyramine foods like aged cheese or cured meats, which may raise blood pressure. Limit alcohol and discuss all medications or supplements with your doctor. Always follow medical advice to stay safe.
