What is Xadago?
Xadago for Parkinson’s Disease can lessen both the signs and symptoms of off periods as well as how long they endure. An “Off Period” is the term used to describe this abrupt reappearance of symptoms.
Parkinson’s disease with “off” episodes is treated with the medication Safinamide brand name: Xadago, which has a number of different mechanisms of action, including the inhibition of monoamine oxidase B.
Levodopa/Carbidopa effects wane between doses, causing off periods. The Food and Drug Administration (FDA) has given it the go-ahead to treat adults with Parkinson’s disease (PD). It is a disorder of the neurological system, PD. Adults who are taking the PD drug levodopa/carbidopa and experience a sudden recurrence of symptoms may be prescribed Xadago.
Xadago Use:
Xadago for Parkinson’s disease is used as an adjunct therapy to a steady dose of levodopa (L-dopa) alone or in conjunction with other PD medications in mid to late-stage fluctuating patients.
Levodopa/carbidopa and Xadago (safinamide) are combined to treat the symptoms of Parkinson’s disease. It can aid in alleviating symptoms like trembling, stiffness, and difficulty moving. Additionally, it may aid in minimizing “off” time (periods of slow movement or stiffness).
Xadago generic: Safinamide is a member of the MAO inhibitor drug subclass. It functions by raising the concentrations of specific natural chemicals in the brain (such as dopamine). Too little dopamine in the brain is assumed to be the cause of Parkinson’s disease.
Xadago Cost:
The most popular type of Xadago has a co-pay of $60.00 to $75.00 and is covered by 61% of insurance plans; however, some Xadago coupons or cash pricing may be lower. The lowest cost for the most popular Xadago dosage is approximately $1,053.90, which is 11% less expensive than the typical retail cost of $1,195.16.
For 50mg: 30 tablets: Xadago for Parkinson’s Disease Costing can vary from $1053 to $1200.
Where to buy Xadago For Parkinson’s Disease?
Xadago for Parkinson’s Disease is available online at much cheaper rates than physical pharmacies. E-pharmacies like LifeRx Pharmacy provide discounts additional to cheaper rates on 30-day medicine supplies.
Check Xadago discount on LifeRx Pharmacy.
Xadago Medication Usage:
Before starting to use Xadago for Parkinson’s Disease and each time you get a refill, read the Patient Information Leaflet if it is available from your pharmacist. Ask your physician or pharmacist if you have any queries. Take this medication by mouth once daily, generally with or without a meal, as prescribed by your doctor.
Your medical condition and treatment response will determine the dosage. Never take more of it or take it more frequently than directed. Your condition won’t get better any faster, and your chance of experiencing negative effects will rise. To reap the greatest benefits from this drug, take it frequently. Take it at the same time every day to aid in memory.
The typical dose of Xadago:
50 mg of Xadago, taken once daily (at the same time), orally, without regard to meals, is the starting dose that is advised.
Depending on the patient’s needs and tolerance, the dosage of Xadago for Parkinson’s Disease may be increased to 100 mg once daily after two weeks.
Taking more than 100 mg per day has not proven to be beneficial.
Xadago Mechanism of Action:
Both dopaminergic and non-dopaminergic modes of action are used by Xadago for Parkinson’s Disease. A rise in the extracellular levels of dopamine in the striatum is brought on by the highly specific and reversible MAO-B inhibitor safinamide.
Inhibition of MAO-B activity, by blocking the catabolism of dopamine, is thought to result in an increase in dopamine levels and a subsequent increase in dopaminergic activity in the brain.
The effects of Xadago for Parkinson’s Disease include state-dependent blockage of voltage-gated sodium (Na+) channels and modulation of glutamate’s stimulated release. It is unknown how much the non-dopaminergic effects influence the overall outcome.
You can avail of Xadago for Parkinson’s disease from the LRP website at a much lower cost than the physical stores. Coupons and Offers are also available for discounts. A prescription is required to buy this item.
Xadago Side Effects:
- Drowsiness or vertigo could happen. Inform your doctor or pharmacist as soon as possible if either of these side effects persists or worsens.
- Get up carefully when leaving a sitting or lying position to lessen the chance of feeling lightheaded or dizzy, especially when you first begin taking safinamide.
- If you have any severe side effects from Xadago for Parkinson’s Disease, such as dizziness, loss of balance, mental or emotional problems (such as anxiety, agitation, or hallucinations), worsening muscle stiffness or twitching, uncontrollable movements, or unusually strong impulses, contact your doctor straight once (such as increased gambling, increased sexual urges).
- Some safinamide users have experienced unexpected sleepiness during routine everyday tasks (such as talking on the phone and driving). In some situations, sleep came on its own, without any prior signs of sleepiness. Even if you have used Xadago for a long period, this sleep effect might happen at any time during treatment.
- Do not drive or engage in any other potentially hazardous activities if you experience greater tiredness or find yourself nodding off during the day until you have addressed this effect with your doctor. If you use alcohol or other drugs that can make you sleepy, your risk of experiencing this sleep effect increases.
- A highly hazardous condition known as serotonin syndrome/toxicity, which is caused infrequently by this Xadago for Parkinson’s Disease, may raise serotonin levels. Tell your doctor or pharmacist about all the medications you use because the risk increases if you also take other medications that raise serotonin. Immediately seek medical attention if any of the following symptoms appear: fast heartbeat, dizziness, nausea, vomiting, or diarrhea that is severe, twitching muscles, fever without apparent cause, and extreme anxiety or restlessness.
- Rarely, this Xadago for Parkinson’s disease may result in an attack or hypertensive crisis, which can be fatal. This risk may rise due to numerous medicine and dietary combinations. If any of the following serious side effects manifest: a severe headache, a fast, slow, irregular, or pounding heartbeat, chest pain, neck stiffness or soreness, severe nausea or vomiting, sweating or clammy skin (sometimes accompanied by fever), widened pupils, vision changes (such as double or blurred vision), or sudden sensitivity to light, seek medical attention right away (photophobia).
- Rarely will this medication (Xadago for Parkinson’s Disease) cause a very serious allergic reaction, however, if you experience any major adverse reaction symptoms, such as a rash, itching, or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing, seek medical attention right away.
The list of potential negative effects is not exhaustive. Contact your doctor or pharmacist if you have any other side effects not covered above.
Xadago Interactions:
Some drugs such as Apraclonidine, bupropion, buspirone, carbamazepine, diet pills/appetizers (such as diethylpropion), deutetrabenazine, dextromethorphan, methyldopa, metoclopramide, specific supplements (such as tryptophan, tyramine), tetrabenazine, some “triptans” used to treat migraines can interact with Xadago.
If you are also taking other medications that elevate serotonin, your chance of developing serotonin syndrome or poisoning rises. Street drugs like MDMA/”ecstasy,” St. John’s wort, some antidepressants (like trazodone, SSRIs like fluoxetine/paroxetine, SNRIs like duloxetine/venlafaxine, tricyclics like amitriptyline/doxepin), medications for attention deficit disorder (like amphetamine, methylphenidate), cyclobenzaprine, and some opioid drugs (such as meperidine, methadone, propoxyphene, tramadol).
If you take certain products along with Xadago for Parkinson’s disease, or even weeks before or after taking Xadago, there may be an interaction. If you take anything on the list of products that could interact with this medication or any products that raise serotonin levels within 2 weeks of taking safinamide, let your doctor or pharmacist know.
Taking this medication along with other MAO inhibitors may result in a dangerous (potentially deadly) drug interaction. While using this drug, avoid using any other MAO inhibitors. The majority of MAO inhibitors should be avoided for two weeks before and following treatment with this drug. Consult your doctor.
Examples: Isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, and tranylcypromine.
Before taking Xadago for Parkinson’s Disease, let your doctor know if you use any medications, including herbal remedies (such ephedra/ma Huang), allergy and cold medications (including decongestants like phenylephrine/pseudoephedrine), stimulants, and medications for allergies and coughing and colds (such as amphetamines, ephedrine, epinephrine, phenylalanine). For more information, consult your physician or pharmacist.
How should Xadago be taken?
- Always take this medication exactly as directed by your doctor. If you’re unsure, consult your doctor. One 50 mg tablet, which may be increased to one 100 mg tablet, taken once a day by mouth with water is the suggested starting dose for Xadago.
- You can take Xadago with or without food.
- Safinamide should not be used alone; it must be administered along with Levodopa and Carbidopa.
- Usually, Xadago for Parkinson’s Disease is given once a day at the same time every day. Xadago (Safinamide) can be taken with or without food. You’ll need to have your blood pressure checked frequently. Keep the medicine at room temperature and away from heat and moisture.
- Without first consulting your doctor, do not discontinue using this drug. When this medication is abruptly stopped, certain conditions could get worse. It could be necessary to gradually reduce your dosage.
Xadago Alternatives:
Your physician may recommend a variety of drugs in place of Xadago for Parkinson’s disease (Safinamide). Compare a few potential substitutes below.
Xadago vs Rasagiline:
An MAO-B inhibitor called Azilect (Rasagiline) is used to treat Parkinson’s disease symptoms. Levodopa and Azilect are sometimes combined in medical treatments.
Dizziness, spinning sensation, joint pain, headache, depression, heartburn, fever, muscle pain, dry mouth, stomach upset or abdominal pain, hair loss, skin rash, numbness or tingling feeling, loss of appetite, constipation, diarrhea, vomiting, weight loss, impotence, loss of interest in sex, difficulty having an orgasm, strange dreams, and flu symptoms are among the side effects of Azilect that are different from those of Xadago.
Antidepressants and opioids may interact with both Xadago and Azilect.
Patients with Parkinson’s disease are advised to take 1 mg of Azilect once daily or as prescribed whereas, Xadago for Parkinson’s Disease recommended starting dose is 50 mg taken orally once daily at the same time; after two weeks, the amount may be increased to 100 mg once daily, depending on the patient’s needs and tolerance.
Xadago vs Selegiline:
Selegiline is a type of generic (unbranded) MAO-B inhibitor medication. Eldepryl and Zelapar are the branded versions of Selegiline.
This drug is used to treat Parkinson’s disease-related movement abnormalities. Although it doesn’t treat Parkinson’s disease, it may lessen tremors, muscular stiffness, loss of normal mobility as other Parkinson’s medications wear out (end-of-dose failure), and abrupt changes between normal movement and stiffness (“on-off” problems).
The dosage of Selegiline is started at 5 mg and increased after two to four weeks to 10 mg.
For individuals who have not responded to previous pharmacological options for PD, Xadago for Parkinson’s disease should be considered for inclusion in the formulary. Xadago acts on the glutamatergic pathway and lacks methamphetamine metabolites, in contrast to the MAO-B inhibitors Selegiline and Rasagiline, which cause dyskinesia as a side effect in individuals with severe Parkinson’s disease.
Hence, Researchers have hypothesized that Xadago for Parkinson’s Disease may have greater beneficial benefits than Selegiline or Rasagiline due to its mode of action.
The Effectiveness Of Xadago:
Xadago(Safinamide) has been shown to be safe and effective for treating motor symptoms in PD patients who are stable on dopamine agonists but fluctuate on levodopa in randomized, double-blind, placebo-controlled trials.
Xadago for Parkinson’s Disease significantly improved daily “on-time” and kept it up for at least two years in the studies without significantly increasing dyskinesia. Moreover, symptom improvement is significant with Xadago.
For individuals who have not responded to previous pharmacological options for PD, Xadago should be considered for inclusion in the formulary. This acts on the glutamatergic pathway and lacks methamphetamine metabolites, in contrast to the MAO-B inhibitors selegiline and rasagiline, which cause dyskinesia as a side effect in individuals with severe Parkinson’s disease.
Xadago comes in 50 mg and 100 mg tablet form. For any strength, a 30-day supply costs $1100. on average at wholesale.
Other than the recognised safety concerns previously connected with the use of MAO-B inhibitors, no unique or new adverse effects were noticed with the medication.
The same efficacy is not established in pediatric patients.
FAQs:
What are the positive effects of the drug Xadago in battling Parkinson’s disease?
Xadago can aid in alleviating symptoms like trembling, stiffness, and difficulty moving. Additionally, it may aid in minimizing “off” time (periods of slow movement or stiffness). Safinamide is a member of the MAO inhibitor drug subclass.
How does drinking alcohol interact with Xadago?
When used with ethanol, Xadago (safinamide) may intensify negative symptoms such as tiredness, disorientation, and difficulty concentrating. Additionally, some people may have trouble thinking, making decisions, and coordinating their movements. While receiving safinamide treatment, alcohol usage should be avoided or restricted.
How does Xadago For Parkinson’s Disease help?
Xadago extends the amount of time that symptoms are under control and reduces the overall amount of time each day that symptoms are present (or “off” time) (“on” time). It is a supplement to levodopa and may enable some patients to use less levodopa daily to manage their symptoms.
Is Xadago an MAO?
Xadago (Safinamide) is a member of the MAO inhibitor drug subclass. It functions by raising the concentrations of specific natural chemicals in the brain (such as dopamine). Too little dopamine in the brain is assumed to be the cause of Parkinson’s disease.
How does Xadago work with Rytary?
Rytary contains Carbidopa and Levodopa. This combination is primarily used to treat the symptoms of PD. This is an add-on therapy with Xadago for Parkinson’s Disease.
Can Xadago make you lose weight?
Very rare (0.1% to 1%). Xadago’s rare side effect includes: decreased appetite and weight loss
Can 100 mg Xadago be cut in half?
No medicine is suggested to be cut into halves or crushed. Not recommended.
What is the best time to take Xadago?
Once daily, usually, mornings are the suggestive time to take that medicine.
Do I take Xadago with food?
Usually, Xadago is given once a day at the same time every day and can be taken with or without food.
Does Iron interfere with Safinamide?
Safinamide (Xadago for Parkinson’s disease) appear to be impeded from being absorbed by iron by adhering to them. According to studies, iron supplementation lowers the blood levels of this medicine by 30 to 51%, and thus worsens Parkinson’s disease symptoms.
