Constella (Linaclotide)
Constella is a medication used to treat certain bowel disorders. It works by increasing the amount of water in the intestine, which helps to soften the stool and make it easier to pass. Constella(Linaclotide) is also thought to help reduce the amount of time the intestine takes to move stool through the digestive tract.
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Constella (Linaclotide) Medication information:
What is Constella?
Each capsule contains 290 micrograms of linaclotide. The active substance in Constella, linaclotide, attaches to some receptors in the gut called guanylate cyclase C. By attaching to these receptors, it reduces pain and increases the secretion of fluid into the gut, thereby loosening the stools and increasing bowel movements.
What is Constella (Linaclotide) used for?
Constella contains the active substance Linaclotide. It is used to treat the symptoms of moderate to severe irritable bowel syndrome (often just called “IBS”) with constipation in adult patients.
IBS is a common gut disorder. The main symptoms of IBS with constipation include:
- Stomach or abdominal pain.
- Feeling bloated,
- Infrequent, hard, small, or pellet-like stools (feces).
How does Constella work?
Constella acts locally in your gut, helping you to feel less pain and less bloated, and to restore the normal functioning of your bowels. It is not absorbed into the body but attaches to a receptor called guanylate cyclase C on the surface of your gut. Attaching to this receptor blocks the sensation of pain and allows liquid to enter the body into the gut, thereby loosening the stools and increasing your bowel movements.
Directions:
How to take it?
The recommended dose is one capsule (i.e. 290 micrograms of linaclotide) taken orally once a day. The capsule should be taken at least 30 minutes before a meal. If you have not experienced an improvement in your symptoms after 4 weeks of treatment, you should contact your doctor.
If you take more Constella than you should. The most likely effect of taking too much Constella is diarrhea. Contact your doctor or pharmacist if you have taken too much of this medicine.
Constella Side Effects:
Common side effects (may affect up to 1 in 10 people):
- Diarrhea
- Stomach or abdominal pain.
- Feeling bloated.
- Wind
- Stomach flu (viral gastroenteritis).
- Feeling dizzy.
Uncommon side effects (may affect up to 1 in 100 people):
- Lack of control over passing stools (fecal incontinence).
- The urgency to pass stools.
- Feeling lightheaded after standing up quickly.
- Dehydration
- Low level of potassium in your blood.
- Decreased appetite.
- Rectal bleeding.
- Bleeding from the bowel or rectum including bleeding from piles/hemorrhoids.
- Nausea
- Vomiting
- Hives (Urticaria).
Constella Precautions:
Here are some precautions to consider when using Constella:
- Inform your healthcare provider of any known allergies or sensitivities to linaclotide or other ingredients in Constella.
- Provide your healthcare provider with a comprehensive medical history, including any gastrointestinal conditions, surgeries, or other health issues.
- If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Constella with your healthcare provider.
- Constella is not indicated for use in children and adolescents under 18 years of age.
- Elderly individuals may be more susceptible to certain side effects of Constella, such as diarrhea. Dosage adjustments or monitoring may be necessary for this population.
- Inform your healthcare provider of all medications, supplements, and herbal products you are taking, as they may interact with Constella. Certain medications, such as opioids or antidiarrheal agents, may reduce the effectiveness of Constella or increase the risk of side effects.
How to store Constella?
- Keep this medicine out of the sight and reach of children. Do not give this medicine to children and adolescents under the age of 18 years because the safety and efficacy of Constella in this age group have not been established.
- Once the bottle is opened, the capsules should be used within 18 weeks.
- Do not store above 30°C. Keep the bottle tightly closed to protect it from moisture.
Constella Drug interactions:
Listed below are Constella drug interactions:
- Oral Medications: Constella is minimally absorbed into the bloodstream after oral administration, Like Ibuprofen, and Omeprazole.
- Antidiarrheal Medications: Imodium, Loperamide.
- Opioid Medications: Morphine, Fentanyl.
- Other Gastrointestinal Medications: Some medications are used to treat gastrointestinal conditions, such as proton pump inhibitors (PPIs) or H2-receptor antagonists.
- Interactions with Specific Drugs: While Constella is generally well-tolerated and has a low potential for significant drug interactions, it's essential to discuss its use with your healthcare provider.
What if you overdose on Constella?
Potential Symptoms of Overdose include Severe Diarrhea, Dehydration, Electrolyte Imbalance, Abdominal Pain, and Nausea. Immediate Actions can include Stop Taking the Medication: Discontinue use of Constella right away. Seek Medical Attention. Hydrate, and Avoid Self-Medication. Medical Treatment includes IV Fluids and electrolyte Replacement is done to correct imbalances. Monitoring with Supportive Care.
Buy Constella Online:
Buy Constella online from Liferx pharmacy. An online platform that provides Constella and other branded or generic medicines at the best Constella cost online to reduce your pocket costs and increase your savings.
LifeRx Pharmacy provides solutions to the high Constella cost. Their prices are clocked at much lower than the mainstream pharmacies to help customers access the medicines that are usually expensive.
Why is Constella so expensive?
The development involves extensive research, including preclinical studies and clinical trials to assess safety and efficacy which caused Constella price to go up. These research and development (R&D) costs are often substantial and may contribute to the pricing of the medication. Moreover, Manufacturing pharmaceuticals involves complex processes and quality control measures to ensure safety and efficacy making Constella price increase significantly.
Does Constella cause weight gain?
Constella primarily works by increasing fluid secretion in the intestines, accelerating bowel movements, and reducing symptoms such as abdominal pain and constipation. It does not typically affect metabolism or appetite in a way that would lead to weight gain.
Is Constella available over the counter?
Constella is not available over the counter (OTC). As a prescription medication, Constella can only be obtained with a valid prescription from a licensed healthcare provider, such as a doctor or nurse practitioner or you can buy Constella online from LifeRx Pharmacy.
How long does it take for Constella to work?
Constella (Linaclotide) typically starts to work within the first week of treatment, although individual responses may vary. It's important to note that Constella is not a medication that immediately relieves symptoms; rather, it works gradually over time to improve symptoms of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC).
Can you take Constella at night?
Yes, Constella can be taken at night but is typically taken once daily, preferably in the morning, on an empty stomach, at least 30 minutes before the day’s first meal. However, some people may prefer to take Constella at night due to personal preferences or convenience. While there is no specific requirement to take Constella at a particular time of day.
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