Lenvima (Lenvatinib)

Lenvima (Lenvatinib) Medication Information:

What is Lenvima?

Lenvima is a brand-prescribed medication used to treat different kinds of cancer. It is used to treat differentiated thyroid carcinoma that is resistant to radioactive iodine. To treat advanced RCC, it is frequently coupled with everolimus. It is furthermore also employed as a first-line therapy for individuals with incurable HCC.

For individuals with endometrial cancer who are not candidates for radiation therapy or surgery, it is administered in combination with pembrolizumab. It is a Kinase inhibitor class of medication that prevents one or more protein kinases from acting, preventing the development and metastasis of cancer cells inside the body.

Uses and Benefits of Lenvima:

Some of Lenvima’s uses and benefits include:

• It aids in the management of advanced thyroid cancer that is resistant to radioactive iodine treatment.
• It offers a combined therapy strategy that can help people with advanced RCC who have failed prior therapies.
• It offers patients with liver cancer, who are not eligible for surgical resection, a new therapy option that could improve overall survival and better manage the disease.
• It offers a useful choice for people with recurrent or advanced endometrial cancer, especially when paired with an immune checkpoint inhibitor.
• It helps stop the development and spread of cancer cells by targeting certain receptors implicated in angiogenesis and tumor growth.
• It significantly improves disease control by extending progression-free survival in several malignancies.

Side Effects of Lenvima:

Some of the common side effects include:

• High blood pressure
• Fatigue or Tiredness
• Diarrhea
• Feeling Nausea and Vomiting.
• Reduced Appetite
• Weight loss
• Redness, swelling, and soreness on the palms of the hands and soles of the feet.
• Pain in the Abdomen.

Some of the serious side effects are:

• Malfunction or injury to the liver.
• Perforation of the stomach.
• Thromboembolic events in the arteries.
• Impairment of the kidneys.
• High protein content in the pee.
• Bleeding Risk

How to use Lenvima?

• Oral administration of Lenvima (Lenvatinib) is usually administered.
• The recommended dose for thyroid cancer is 24 mg once daily.
• The recommended dose for renal cell carcinoma (RCC) is 18 mg once a day, frequently in combination with everolimus (5 mg daily).
• The recommended dose for hepatocellular carcinoma (HCC) is 8 mg once daily in patients under 60 kg in weight and for people weighing 60 kg or more, 12 mg once a day.
• For endometrial cancer, the suggested dosage is 20 mg once daily along with 200 mg of pembrolizumab every three weeks.
• Along With a full glass of water, swallow the whole capsule.
• Do not break, chew, or crush the capsules.
• If a dose is missed, just skip it and take the subsequent dosage at the scheduled time. To make up for a missing dose, never take two doses at once.
• You can take Lenvima with or without meals. To prevent variances in absorption, it is advisable to stick to a regular schedule for meal consumption.

Lenvima Drug Interactions:

Some of the listed drug interactions with Lenvima are:

• Medications that stimulate or block CYP3A4 for eg: Ritonavir, Clarithromycin, Itraconazole, and Ketoconazole.
• Medications metabolized by CYP3A4 for instance, Atorvastatin, Midazolam, and Tacrolimus.
• Medications such as Clopidogrel, Warfarin, Aspirin, and direct oral anticoagulants (DOACs).
• Antacids and proton pump inhibitors, like Ranitidine and Omeprazole
• Other anticancer medications.

Lenvima Precautions:

Major safety measures to consider when taking Lenvima:

• Monitor blood pressure often since Lenvima may aggravate or exacerbate hypertension.
• Check liver and kidney function tests (LFTs) often since proteinuria and hepatotoxicity can be caused by Lenvima. Lenvima dosage changes or cessation may be required if liver enzyme values rise noticeably.
• Keep an eye out for indications of infection or severe abdominal discomfort, which are indicators of gastrointestinal perforation.
• If you use anticoagulants or antiplatelets, be extra alert for any indications of bleeding or hemorrhage.
• Keep an eye out for symptoms of a heart attack or stroke, such as trouble speaking, sudden weakness, or chest discomfort.
• Seek prompt medical attention and determine whether therapy modifications are necessary if any arterial thromboembolic event symptoms appear.
• Lenvima should not be used when pregnant since it might damage the fetus.
• Lenvima may interfere with wound healing, so if you're having surgery, proceed cautiously.
• Individuals who already have underlying medical issues such as liver impairment, cardiovascular disease, or gastrointestinal disorders need to be constantly watched. Adapt treatment regimens to each patient's unique health situation and therapeutic response.

Buy Lenvima Online:

Lenvima cost varies based on different factors like its strength, quantity, dosage, and manufacturer’s country. Lenvima cost is quite high due to the non-availability of its generic medication. However, One can easily buy Lenvima online from LifeRX Pharmacy which is one of the branded and trusted online pharmacy platforms. It ensures a flawless online pharmacy experience that combines dependability, comfort, and individualized attention.

How effective is Lenvima?

Lenvima has shown its efficacy in treating a variety of malignancies, including endometrial, thyroid, hepatocellular, and renal cell tumors. It frequently improves overall outcomes and progression-free survival. However, depending on the cancer kind and each person's reaction, effectiveness can vary.

Is Lenvima chemotherapy?

No, Lenvima is not chemotherapy. It is a tyrosine kinase inhibitor and targeted treatment that selectively inhibits several enzymes involved in the development of cancer.

Do Lenvima side effects go away?

Over time, Lenvima side effects may become better or go away, especially with dosage modifications or supportive care. Some adverse effects, nevertheless, cannot go away or need constant attention if they are persistent. For advice, always speak with your healthcare practitioner.

Can Lenvima cause blood clots?

Yes, Lenvima can increase the risk of blood clots (thromboembolic events). Therefore it is advised to be vigilant about symptoms and discuss any concerns with your healthcare provider if taking anticoagulants or antiplatelet medications.

Can you drink alcohol while taking Lenvima?

When using Lenvima (Lenvatinib), it is typically advised to minimize or prevent alcohol consumption. Alcohol might make adverse effects worse, such as gastrointestinal problems and liver damage. Always get individual guidance from your healthcare professional before consuming alcohol while undergoing treatment.

References:

• https://www.drugs.com/lenvima.html
• https://www.lenvima.com/
• https://www.drugs.com/price-guide/lenvima