Pradaxa (Dabigatran Etexilate)

Pradaxa (Dabigatran Etexilate) Medication Information:

What is Pradaxa?

Pradaxa (Dabigatran Etexilate) is an oral anticoagulant (blood thinner) used to reduce the risk of stroke and blood clots in people with certain types of irregular heartbeat, such as non-valvular atrial fibrillation. It works by inhibiting thrombin, an enzyme in the blood that is crucial for clot formation.

Pradaxa is also used to treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients who have been treated with an injectable blood thinner for 5 to 10 days. Additionally, it is used to prevent DVT and PE after hip replacement surgery.

Uses and Benefits of Pradaxa:

• Prevention of Stroke and Systemic Embolism.
• Treatment and Prevention of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE).
• Post-Surgical Blood Clot Prevention.

Side Effects of Pradaxa:

Common side effects of Pradaxa:

• Minor bleeding (e.g., bruising, nosebleeds, bleeding gums).
• Gastrointestinal bleeding
• Dyspepsia (indigestion)
• Nausea
• Stomach discomfort or pain
• Heartburn
• Fatigue
• Weakness

Serious Side Effects:

• Severe bleeding (e.g., intracranial hemorrhage, gastrointestinal bleeding)
• Allergic reactions (e.g., anaphylaxis, hives, rash)
• Kidney problems (e.g., worsening kidney function)
• Liver dysfunction (rare)
• Thrombocytopenia (rare, low platelet count)

How to use Pradaxa?

• Oral administration of 150 mg twice daily is the standard dosage for the prevention of stroke in patients with non-valvular atrial fibrillation.
• The dosage may be changed to 75 mg twice a day for patients with kidney impairment or other particular conditions, or as prescribed by your physician.
• Adhere to the recommended dosage of Pradaxa, which is usually one capsule in the morning and one in the evening.
• It's crucial to take the medication at the same time every day to keep your blood levels constant.
• Drink a full glass of water after swallowing the capsule completely. The drug's absorption may be impacted if the capsule is chewed, crushed, or opened.
• Although Pradaxa can be taken with or without food, doing so may lessen stomach discomfort.

Pradaxa Drug Interactions:

Here is a list of potential drug interactions with Pradaxa:

• Anticoagulants such as Warfarin, Heparin, and Other blood thinners.
• Antiplatelet Drugs such as Aspirin, Clopidogrel (Plavix), and Ticlopidine.
• Nonsteroidal Anti-inflammatory Drugs (NSAIDs) such as Ibuprofen, and Naproxen.
• P-glycoprotein (P-gp) Inhibitors such as Verapamil, Ketoconazole, Dronedarone, Amiodarone, and Quinidine.
• P-glycoprotein (P-gp) Inducers such as Rifampin, St. John’s Wort.
• Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) such as Fluoxetine, Sertraline, and Venlafaxine.
• Proton Pump Inhibitors (PPIs) such as Omeprazole.

Pradaxa Precautions:

• Pradaxa can increase the risk of serious bleeding, including fatal bleeding. Patients should avoid activities that may increase the risk of injury or bleeding.
• Dose adjustment may be required in patients with impaired kidney function. Monitoring kidney function periodically is essential.
• Pradaxa can cause gastrointestinal problems such as stomach pain, indigestion, and bleeding ulcers. Take it with food to reduce stomach upset.
• Inform your healthcare provider if you need surgery or any invasive procedure. Pradaxa may need to be stopped beforehand due to the risk of bleeding.
• Patients undergoing spinal or epidural anesthesia are at risk of developing a hematoma, which can lead to paralysis. Close monitoring is required.
• Caution should be taken in patients with liver impairment, as liver disease can affect Pradaxa’s metabolism and increase the risk of bleeding.
• The safety of Pradaxa during pregnancy and breastfeeding is not well established. Consult your doctor before use if you are pregnant or breastfeeding.

Buy Pradaxa Online:

When one goes to buy Pradaxa online, it's crucial to prioritize safety and authenticity. Pradaxa is a prescription medication used to prevent strokes and blood clots, so it’s important to obtain it from a reputable and licensed pharmacy. Before you buy Pradaxa online, ensure that the online pharmacy is accredited and genuine.

Online buying helps to reduce the Pradaxa price. However, to guarantee the security and legitimacy of the drug, it's critical to choose reliable and authorized online pharmacies. One can buy Pradaxa online from LifeRx Pharmacy for a good Pradaxa cost and availability.

How long to hold Pradaxa before surgery?

Before undergoing surgery, it's crucial to manage the timing of Pradaxa (Dabigatran) to minimize the risk of bleeding while ensuring effective anticoagulation. Typically, Pradaxa should be stopped 1 to 2 days before a planned surgical procedure, depending on the type of surgery and the patient's renal function.

Can Pradaxa be crushed?

Pradaxa should not be crushed, chewed, or broken. The medication is designed to be swallowed whole, and altering its form can affect how the drug is absorbed and its effectiveness.

Is Pradaxa generic?

The generic Pradaxa is accessible in capsule form. Buy Pradaxa online from LifeRx Pharmacy.

Does Pradaxa affect blood pressure?

No, Pradaxa is primarily an anticoagulant used to prevent blood clots and reduce the risk of stroke, rather than a medication designed to directly affect blood pressure. It works by inhibiting a specific clotting factor in the blood, thereby reducing the likelihood of clot formation.

Why is Pradaxa so expensive?

Pradaxa is often expensive due to several factors, including its status as a brand-name drug with patented protection, which limits the availability of cheaper generic alternatives. The high cost is also attributed to the extensive research and development required to bring a new medication to market, including clinical trials and regulatory approvals.

References:

• https://www.medicalnewstoday.com/articles/drugs-pradaxa-cost
• https://patient.boehringer-ingelheim.com/us/pradaxa/
• https://my.clevelandclinic.org/health/drugs/20272-dabigatran-oral-capsules