Tecfidera (Dimethyl Fumarate)

Tecfidera (Dimethyl Fumarate) Medication Information:

What is Tecfidera?

Tecfidera (Dimethyl Fumarate) is a prescription medication primarily used to treat multiple sclerosis (MS), a chronic disease that affects the central nervous system. Tecfidera is an oral medication, typically taken in capsule form, and is classified as a disease-modifying therapy (DMT).

Tecfidera is believed to work by reducing inflammation and the immune response that can cause damage to the nerves in the brain and spinal cord. Although the exact mechanism of action is not fully understood, it is thought to involve the activation of the Nrf2 pathway, which helps protect cells from oxidative stress.

Uses and Benefits of Tecfidera:

Tecfidera is primarily prescribed for the treatment of relapsing forms of multiple sclerosis (MS), particularly relapsing-remitting multiple sclerosis (RRMS). RRMS is characterized by periods of flare-ups (relapses) followed by periods of partial or complete recovery (remissions). Tecfidera helps reduce the frequency of these relapses and slows the progression of physical disability associated with MS.

Side Effects of Tecfidera:

Here are the names of common side effects of Tecfidera:

• Flushing
• Nausea
• Diarrhea
• Abdominal pain
• Lymphopenia
• Rash
• Itching
• Indigestion
• Vomiting
• Headache

How to use Tecfidera?

Tecfidera is generally recommended as an oral capsule taken two times per day. The typical initial dose is 120 mg two times a day for the first 7 days, followed by an increase to the maintenance dose of 240 mg two times a day. The capsule can be taken as such with water., with or without food. Taking it with food may help reduce the side effects of flushing. Do not crush, chew, or break it.

Tecfidera Drug Interactions:

Some medications and substances that may interact with Tecfidera include:

• Immunosuppressants: Drugs like Azathioprine, Methotrexate, and others that suppress the immune system may increase the risk of infections or other side effects when taken with Tecfidera.
• Other Multiple Sclerosis (MS) Therapies: Combining Tecfidera with other MS treatments may enhance side effects or reduce the effectiveness of one or both medications.
• Live Vaccines: Since Tecfidera affects the immune system, receiving live vaccines while on this medication may increase the risk of infection or reduce the vaccine's effectiveness.
>Medications Affecting the Liver: Drugs that impact liver function, such as certain antibiotics or antifungals, may interact with Tecfidera, as Tecfidera is metabolized in the liver.

Tecfidera Precautions:

When taking Tecfidera, it’s important to follow certain precautions to ensure safe and effective use:

• Regular blood tests are required to monitor white blood cell counts, as Tecfidera can cause lymphopenia (a decrease in white blood cells), increasing the risk of infections.
• Due to its impact on the immune system, Tecfidera may increase the risk of infections. Notify your healthcare provider immediately if you experience symptoms like fever, chills, or persistent cough.
• Tecfidera can affect liver function, so liver enzymes should be monitored periodically. Report any signs of liver issues, such as yellowing of the skin or eyes (Jaundice) or dark urine.
• Tecfidera may cause flushing (redness and warmth of the skin). This is generally mild but can be reduced by taking Tecfidera with food or as advised by your healthcare provider.
• Nausea, diarrhea, and stomach pain are common side effects. These are usually mild but consult your doctor if they become severe or persistent.

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Can Tecfidera cause cancer?

Tecfidera is not known to directly cause cancer. However, it can affect the immune system, potentially increasing the risk of infections or other complications. Regular monitoring is essential to detect any unusual health changes. If you have concerns about cancer risk while taking Tecfidera, consult your healthcare provider for personalized guidance and screening.

Can Tecfidera cause hair loss?

Yes, Tecfidera can cause hair loss in some individuals, although it is not a common side effect. Hair loss may occur due to the medication’s impact on the immune system or other factors. If you experience significant hair loss while taking Tecfidera, consult your healthcare provider to discuss possible management strategies.

Can Tecfidera cause weight gain?

Tecfidera is not typically associated with weight gain. Weight loss or changes in appetite are more commonly reported side effects. If you experience unexpected weight gain while taking Tecfidera, consult your healthcare provider to determine if it could be related to the medication or other factors.

Can you take Tecfidera while pregnant?

No, Tecfidera is not recommended during pregnancy. It is classified as a Category C medication, which means that its safety during pregnancy has not been established, and it may potentially harm the fetus. If you are pregnant or planning to become pregnant, speak about the alternative treatment options with the concerned doctor. Effective contraception should be used while taking Tecfidera to prevent pregnancy.

Can you drink alcohol while taking Tecfidera?

It is generally advised to limit or avoid alcohol consumption while taking Tecfidera. Alcohol can potentially exacerbate some side effects of the medication, such as gastrointestinal issues or liver problems. Additionally, alcohol may affect your immune system, which could interfere with the effectiveness of Tecfidera.

References:

• https://www.tecfidera.com/content/dam/commercial/tecfidera/pat/en_us/pdf/full-prescribing-info.pdf
• https://www.tecfidera.com/en_us/home/another-treatment-option.html